HANU™ reactor enables scalable protocol for slurry-based MacMillan metallaphotoredox Csp2-Csp3 coupling

In their latest Organic Process Research & Development article, Ecosynth reports the application of the HANU™ reactor to enable a heterogeneous MacMillan-type C(sp2)–C(sp3) cross-electrophile coupling. Combination of an oscillatory flow regime with static mixing elements imparts exquisite control over the mixing intensity and residence time distribution, pinpointing a mindset shift concerning slurry handling in continuous flow reactors. The C(sp2)–C(sp3) cross-electrophile coupling was successfully transferred from batch to flow, resulting in an intensified slurry process with significantly reduced reaction time and increased productivity.

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