Company

Creaflow was founded in May 2018, originating from a collaboration between EcoSynth and Ajinomoto OmniChem which aimed at developing scalable and integrated continuous flow units. Creaflow’s aim is to develop and market innovative and scalable continuous flow reactors for customers in the life science and chemical industry.

 

EcoSynth is a CRO whose core service activities are new molecule development, process development and chemical stability assessment. In support of this business, EcoSynth’s R&D focuses on sustainable chemical technologies such as continuous flow chemistry, photochemistry, transesterification catalysis and chemical modification of renewables.

 

Ajinomoto OmniChem is a CMO which, apart from large-scale batch production of pharmaceuticals and fine chemicals, has the capacity and infrastructure to produce in continuous flow under cGMP conditions.

 

 

Creaflow team

Dr. Koen Van Aken

CEO

After obtaining a PhD at the Catholic University of Leuven (Belgium) in 1993, Koen Van Aken (°1965) occupied a postdoctoral position at Georgia State University, Atlanta. Afterwards, he returned to Belgium to join the Center of Molecular Design at Janssen Pharmaceutica (a division of Johnson & Johnson). As senior scientist, his work involved HIV drug design in close collaboration with Dr. Paul Janssen which eventually resulted in FDA approved drugs. After founding the company EcoSynth in 2001, he obtained a master in Innovation & Entrepreneurship at Vlerick Gent Management School (2007). His 23 years of experience in academic and industrial organic chemistry are illustrated by (co)authorship of over 40 publications (including 17 patents). Main interests include sustainable chemistry, flow chemistry, novel activation technologies, optimalization of reaction parameters, automation of organic chemistry and process development. As current guest professor, he teaches “sustainable chemistry” as a course at the Catholic University of Leuven, the same university at which he was appointed fellow of the faculty of science. He was also chairman of the feasibility study for the Flemish Initiative for Sustainable Chemistry and member of the former board of directors of FISCH, now transformed in CATALISTI.

Dr. ing. Hannes Gemoets

R&D Engineer

Hannes P. L. Gemoets was born in Ghent (°1991), Belgium. In 2013, he received a M. Sc. degree in Chemical Engineering (cum laude) at the KU Leuven (Faculty of Engineering Technology Ghent). Later that year, he moved to the Netherlands to pursue his Ph.D. at the Eindhoven University of Technology (TU/e) in the Micro Flow Chemistry & Process Technology group, under the supervision of Prof. Timothy Noël and Prof. Volker Hessel. His research focused on the development of novel continuous-flow methods for C–H functionalization strategies (i.e. C–H activation and photoredox catalysis). As a next step in his career, Hannes joined the Research & Development division of Creaflow located in Deinze, Belgium. As R&D Engineer, his work focusses on the on the design and development of innovative and scalable continuous-flow (photo)reactors.

  

Scientific board

Prof. Timothy Noël

Eindhoven University of Technology

Timothy Noël received in 2004 his MSc degree (Industrial Chemical Engineering) from the KaHo Sint-Lieven in Ghent. He then moved to Ghent University to obtain a PhD at the Laboratory for Organic and Bioorganic Synthesis (2005-2009). Next, he moved to Massachusetts Institute of Technology (MIT) as a Fulbright Postdoctoral Fellow with Professor Stephen L. Buchwald. He currently holds a position as an associate professor and he chairs the Micro Flow Chemistry & Synthetic Methodology group at Eindhoven University of Technology. His research interests are flow chemistry, homogeneous catalysis and organic synthesis. His research on photochemistry in microfluidic reactors was awarded the DECHEMA award 2017.

Prof. Simon Kuhn

KU Leuven

Simon Kuhn received his Diploma in Chemical Engineering from TU Munich and his PhD from ETH Zurich. After a stay as post-doctoral fellow at the Massachusetts Institute of Technology (MIT), he joined the Department of Chemical Engineering at University College London as assistant professor. In 2014, he was appointed as professor in the Department of Chemical Engineering at KU Leuven. His research interests lie in the characterization of transport processes in complex flows using experiments and modeling, scaling-up microchemical systems, and design of novel flow reactors.

Dr. Ir. Wouter Debrouwer

EcoSynth

Wouter Debrouwer (°1988) obtained his MSc in Bioscience Engineering, option chemistry and bioprocess technology, from Ghent University (Belgium, 2011). His PhD, under the supervision of professor Chris Stevens, included the development of synthetic entries toward azaheterocyclic organophosphonates and mechanistic investigations in the gold-catalyzed formation of benzothiophenes and was completed in 2015. Subsequently, he joined the group of prof. Alois Fürstner at the Max-Planck-Institut für Kohlenforschung (Mülheim an der Ruhr, Germany). His postdoctoral research involved the organometallic chemistry of gold carbenes and vinylidenes. In 2017 he joined Ecosynth as senior scientist specializing in continuous flow chemistry, photochemistry and chemical engineering. As such he was part of the R&D team that developed the HANU-reactor.