Scalable Flow Reactors

Pushing the Boundaries of Flow Chemistry

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HANU™ reactor enables scalable protocol for slurry-based MacMillan metallaphotoredox Csp2-Csp3 coupling

HANU™ reactor enables scalable protocol for slurry-based MacMillan metallaphotoredox Csp2-Csp3 coupling

13/04/2020 - 12:15

In their latest Organic Process Research & Development article, Ecosynth reports the application of the HANU™ reactor to enable a heterogeneous MacMillan-type C(sp2)–C(sp3) cross-electrophile coupling. Combination of an oscillatory flow regime with static mixing elements imparts exquisite control over the mixing intensity and residence time distribution, pinpointing a mindset shift concerning slurry handling in continuous flow reactors. The C(sp2)–C(sp3) cross-electrophile coupling was successfully transferred from batch to flow, resulting in an intensified slurry process with significantly reduced reaction time and increased productivity.

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"Unlocking the full potential of flow chemistry" in Speciality Chemicals Magazine

19/03/2020 - 11:16

The article in Specialty Chemicals Magazine (November 2019) describes how the HANU reactors are pushing the boundaries of flow chemistry in terms of scalability, customization and specific chemistries.

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First application notes for the HANU-reactor

07/02/2020 - 11:18

The first application notes demonstrating the HANU-reactor’s potential for photochemically generating kilogram amounts of product are now available on the applications page. Both application notes describe 365 nm light-mediated transformations. The first example is a classic [2+2]-photocycloaddition whereas the other one relies on a photoinitiated radical chain process.

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First pilot version of the HANU-reactor installed at Ajinomoto Bio-Pharma Services

First pilot version of the HANU-reactor installed at Ajinomoto Bio-Pharma Services

17/11/2018 - 11:22

Creaflow has successfully installed a pilot-scale version of the HANU-reactor at the premises of Ajinomoto Bio-Pharma Services in Wetteren, Belgium. This unit enables the scale-up of (photo)chemical processes that were developed and optimized in the lab HANU-reactor. Full implementation of the pilot reactor in a GMP environment is foreseen in early 2019.

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Launch of HANU-reactors with integrated heat exchanger

Launch of HANU-reactors with integrated heat exchanger

03/10/2018 - 12:25

Creaflow has launched an upgraded version of the HANU-reactor featuring an integrated heat exchanger. This upgrade ensures highly efficient energy transfer in the range of -20°C to +80°C. The unit comes with an insulating, chemically resistant PTFE housing and allows superior process thermoregulation.

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