Photochemical Deracemization of a Medicinally-Relevant Benzopyran using an Oscillatory Flow Reactor

Photo-transformation: Unlike classical enantiomeric resolution methods, crystallization-induced diastereomer transformations (CIDTs) allow full conversion to the desired enantiomer. Using photochemical racemization for a CIDT has not before been published in the scientific literature. We report the use of an oscillatory flow reactor for efficient irradiation, allowing high yield and >95 % ee to be achieved in a reaction time of just a few hours.

Photochemical Deracemization of a Medicinally-Relevant Benzopyran using an Oscillatory Flow Reactor - Kappe, C.O. et al. Chem. Eur. J., 2022, https://doi.org/10.1002/chem.202200741

Dr. Jason D. Williams, Dr. Peter Pöchlauer, Dr. Yoshiyuki Okumura, Yukari Inami, Prof. Dr. C. Oliver Kappe​, Chemistry A European Journal, 2022, DOI: 10.1002/chem.202200741

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202200741