Ir/Ni Photoredox Dual Catalysis with Heterogeneous Base Enabled by an Oscillatory Plug Flow Photoreactor. - van Aken, K. et al. Org. Process Res. Dev. 2020, 24, 10, 2319–2325.

ABSTRACT: Continuous flow reactor technology has a proven track record in enabling photochemical transformations. However, transfer of a photochemical batch process to a flow protocol often remains elusive, especially when solid reagents or catalysts are employed. In this work, application of an oscillatory plug flow photoreactor enabled a heterogeneous MacMillan-type C(sp2)–C(sp3) cross-electrophile coupling. Combination of an oscillatory flow regime with static mixing elements imparts exquisite control over the mixing intensity and residence time distribution, pinpointing a mindset shift concerning slurry handling in continuous flow reactors. The C(sp2)–C(sp3) cross-electrophile coupling was successfully transferred from batch to flow, resulting in an intensified slurry process with significantly reduced reaction time and increased productivity (0.87 g/h).

Ir/Ni Photoredox Dual Catalysis with Heterogeneous Base Enabled by an Oscillatory Plug Flow Photoreactor - van Aken, K. et al. Org. Process Res. Dev. 2020, 24 (10), 2319–2325.

Debrouwer, W.; Kimpe, W.; Dangreau, R.; Huvaere, K.; Gemoets, H. P. L.; Mottaghi, M.; Kuhn, S.; van Aken, K. Org. Process Res. Dev. 2020, 24, 10, 2319–2325.

https://doi.org/10.1021/acs.oprd.0c00150.