Scalable Flow Reactors

Pushing the Boundaries of Flow Chemistry

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Creaflow designs, develops and manufactures scalable flow reactors that push the current boundaries in photochemistry & solid-liquid chemistry.

Unique capability of handling solid (photo)catalysts in flow demonstrated

17/05/2020 - 12:08

In a recent article "An oscillatory plug flow photoreactor facilitates semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings" by the Kappe group, it was demonstrated that the HANUTM reactors can efficiently be used to perform scalable flow experiments with heterogeneous catalysts. Open access article The use of the COSTATM technology, which combines an oscillatory flow regime with a microstructured plug flow photoreactor, led to a stable suspension of the photocatalyst, circumvented clogging and improved the residence time distribution (RTD) profile.

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HANU™ reactor enables scalable protocol for slurry-based MacMillan metallaphotoredox Csp2-Csp3 coupling

HANU™ reactor enables scalable protocol for slurry-based MacMillan metallaphotoredox Csp2-Csp3 coupling

13/04/2020 - 12:15

In their latest Organic Process Research & Development article, Ecosynth reports the application of the HANU™ reactor to enable a heterogeneous MacMillan-type C(sp2)–C(sp3) cross-electrophile coupling. Combination of an oscillatory flow regime with static mixing elements imparts exquisite control over the mixing intensity and residence time distribution, pinpointing a mindset shift concerning slurry handling in continuous flow reactors. The C(sp2)–C(sp3) cross-electrophile coupling was successfully transferred from batch to flow, resulting in an intensified slurry process with significantly reduced reaction time and increased productivity.

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"Unlocking the full potential of flow chemistry" in Speciality Chemicals Magazine

19/03/2020 - 11:16

The article in Specialty Chemicals Magazine (November 2019) describes how the HANU reactors are pushing the boundaries of flow chemistry in terms of scalability, customization and specific chemistries.

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First application notes for the HANU-reactor

07/02/2020 - 11:18

The first application notes demonstrating the HANU-reactor’s potential for photochemically generating kilogram amounts of product are now available on the applications page. Both application notes describe 365 nm light-mediated transformations. The first example is a classic [2+2]-photocycloaddition whereas the other one relies on a photoinitiated radical chain process.

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First pilot version of the HANU-reactor installed at Ajinomoto Bio-Pharma Services

First pilot version of the HANU-reactor installed at Ajinomoto Bio-Pharma Services

17/11/2018 - 11:22

Creaflow has successfully installed a pilot-scale version of the HANU-reactor at the premises of Ajinomoto Bio-Pharma Services in Wetteren, Belgium. This unit enables the scale-up of (photo)chemical processes that were developed and optimized in the lab HANU-reactor. Full implementation of the pilot reactor in a GMP environment is foreseen in early 2019.

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