HANU™ Flow Reactors

Flow Reactors

The HANU™ Flow Reactor is a continuous-flow reactor, designed and engineered in order to fulfil specific unmet needs in the flow reactor market.

Based on the COSTA™ Technology, these innovative flow reactors integrate numerous advantages as compared to the current state-of-the-art: a high mixing capacity no matter the flow rate, linear scalability by simply widening the process channel and high customization potential. This goes without compromising energy or mass transfer while improving the plug flow profile.

The assembled reactors can be customised and completely tailored to the reaction kinetics and physicochemical properties of the reaction mixture, such as corrosion resistance and viscosity. As such, specific chemistries that are traditionally difficult to scale come into the picture.

    Scalable UV & VIS Photochemistry

    Both UV and visible light photochemistry can be accessed as the HANU™ reactor can be assembled with a large borosilicate or quartz window. In addition, the dramatically improved degree of turbulence in the process channels ensures fast film refreshment for optimal irradiance of your process steam. As a result, slow photochemical reactions that require long irradiation times can be run in a continuous one-pass operation with no need for recirculation, while ensuring excellent control over the residence time distribution.

    The HANU™ Flow Reactor can easily be scaled-up by simply widening the process channel. This does not affect the specific irradiated area and if all other process parameters are kept constant, in this way a seamless scale-up is obtained from laboratory to the production scale.

    Demanding multi-phase processes

    Apart from enabling scalable photochemistry, the HANU™ Flow Reactor can be applied to the scale-up of demanding multi-phases processes, as it allows the effective mixing of immiscible liquids and guarantees the processing of solid particles in suspension at any flow rate. The effective handling of suspensions containing, for example heterogeneous (photo)catalysts, insoluble APIs or inorganic bases truly opens new avenues in scalable flow (photo)chemistry.

    Multi-purpose solution for cGMP manufacturing

    The HANU™ Flow Reactor complies with the Pressure Equipment Directive PED 2014/68/EU art. 4.3 and irradiation source can be delivered with ATEX certification. Since the HANU reactor is an ‘open-shell’ system, disassembly allows straightforward physical cleaning and swab sampling of the process channels during cleaning validation cycles.

    In this way, the HANU™ Flow Reactor complies with the strict requirements and can be operated as multi-purpose reactor in cGMP manufacturing.

    Non-invasive inline reaction monitoring

    The application of through-window non-invasive spectroscopic analyses makes the reactor particularly useful for process development or integration in cGMP processes. Consequently, at every point of the process channel the composition of the chemical matrix can be monitored via PAT methods. For instance, the point where 100% conversion is reached can be easily detected and the flow rate adapted to optimize reactor performance.

    In terms of process development, kinetic data can be generated and plotted rapidly by means PAT methods, such as Raman and near infrared spectroscopic monitoring of the process stream.

    An application note is available about the implementation of a non-invasive inline Raman spectroscopy as a tool for a real-time kinetic study of a Diels-Alder reaction.

    Visual Inspection

    As every chemists like to look into their round bottom flask. The large transparent window of the HANU Flow Reactor is an invaluable asset that aids as inspection window to visually monitor and understand your particular process. As such, the user may discern liquid-liquid flow regimes, identify colour changes, detect precipitation, etc.